Endocrine Abstracts

Background: Serotonergic signalling has been implicated in numerous hypothalamic functions including circadian rhythmicity, feeding and the modulation of neuroendocrine systems. In spite of the importance of these functions, the neuroanatomy of the serotonergic system in the human hypothalamus is still unknown.Aim and methods: To increase insight in hypothalamic serotonin signalling in humans, we investigated the distribution of serotonin transporters (S...

Background: Previous studies reported that direct injection of estrogen (E2) into different hypothalamic nuclei affects food intake, body weight and locomotor activity. We hypothesized that E2 signaling in the hypothalamus regulates glucose metabolism independently of circulating estrogen levels.Methods: We investigated the effects of hypothalamic estrogen administration on basal glucose production as well as on hepatic and peripher...